Monday, August 3, 2020
Home News COVID-19 Vaccine Generates Immune Response, Well Tolerated

COVID-19 Vaccine Generates Immune Response, Well Tolerated

SEATTLE — An investigational vaccine designed to protect against COVID-19 was generally well tolerated and prompted neutralizing activity in healthy adults, according to interim results published July 14, in the New England Journal of Medicine. The lead author of the study, detailed in “A SARS-CoV-2 mRNA Vaccine — Preliminary Report,” is Lisa A. Jackson, MD, MPH, a senior investigator at Kaiser Permanente Washington Health Research Institute in Seattle.

The ongoing phase 1 trial is supported by the National Institute of Allergy and Infectious Diseases, or NIAID, part of the National Institutes of Health. The experimental vaccine is being co-developed by researchers at NIAID and Moderna Inc. of Cambridge, Massachusetts. Manufactured by Moderna, mRNA-1273 is designed to induce neutralizing activity to block the virus from binding to and entering human cells.

The first study vaccination was administered on March 16 at Kaiser Permanente Washington Health Research Institute. The interim report details the findings from the first 45 participants ages 18 to 55 years enrolled at the study sites in Seattle and Emory University in Atlanta through 57 days after their first vaccination. Three groups of 15 volunteers received 2 intramuscular injections, 28 days apart, of either 25, 100, or 250 micrograms of the investigational vaccine.

In April, the trial was expanded to enroll adults older than 55 years; it now has 120 participants. However, the newly published results cover the 18- to 55-year age group only.

Regarding safety, no serious adverse events were reported. More than half of the participants reported symptoms including fatigue, headache, chills, muscle aches, or pain at the injection site. Symptoms were more common following the second vaccination and in those who received the highest vaccine dose. Data on side effects and immune responses at various vaccine dosages informed the doses used or planned for use in the phase 2 and 3 clinical trials of the investigational vaccine.

The interim analysis reports on the levels of vaccine-induced neutralizing activity — through days 43 to 57 — after the second injection. Two doses of vaccine prompted high levels of neutralizing activity that were above the average values seen in convalescent serum obtained from people with confirmed cases of COVID-19 disease.

A phase 2 clinical trial of mRNA-1273, sponsored by Moderna, began enrollment in late May. Plans are underway to launch a phase 3 efficacy trial in July 2020.

The COVID-19 Prevention Trials Network has a volunteer screening registry of people nationwide who are interested in participating in a range of vaccines and other preventive treatments at various research facilities in Seattle and around the country: coronaviruspreventionnetwork.org.

Kaiser Permanente Washington’s vaccine research group has a registry of Seattle-area people who want to be considered to participate in possible trials of investigational vaccines for COVID-19 at Kaiser Permanente Washington in Seattle: corona.kpwashingtonresearch.org.

Additional information about the phase 1 trial design is available at clinicaltrials.gov using the identifier NCT04283461. This trial was supported in part by NIAID grants UM1AI148373 (Kaiser Permanente Washington), UM1AI148576 (Emory University), and UM1AI148684 (Infectious Diseases Clinical Research Consortium). The Coalition for Epidemic Preparedness Innovations, or CEPI, provided funding for the manufacture of mRNA-1273 phase 1 material.

Read more about Kaiser Permanente’s research on vaccines.

Most Popular

Let Your Voice Be Heard

During this unprecedented time, public comment during board meetings has transitioned from in-person to call-in, which has substantially increased public access and...

The Tipping Point!

By Robert Lee Johnson The general assembly of the Commonwealth of Virginia in 1669 addressed the killing of...

Protests”: In Portland, Getting Out of Jail Requires Relinquishing Constitutional Rights

Federal authorities are using a new tactic in their battle against protesters in Portland, Oregon

Governor Newsom Takes Action to Strengthen State Unemployment Insurance Delivery System

This includes the formation of an Employment Development Department or EDD strike team, and a renewed focus on processing unpaid claims.

Recent Comments

Antifa are the real fascists on The Truth About Antifa
Artemis Gordon on The Truth About Antifa
Vicky Palesa Adam on Lung Health Tips for COVID-19
J.S on Icarus Falls
Ghost from your past! on Icarus Falls
Lisa Bennett on The Truth About Antifa
Dave on Icarus Falls
Kevin on Icarus Falls
DAVID J LEE on Think: George Floyd
M Mackey on Think: George Floyd
Michael S. Motta on Think: George Floyd
Thomas "HOUSE" Houchens on Think: George Floyd
Eliath Mena on Think: George Floyd
Deidre Powell on Think: George Floyd
Marcia Ladymgirl on Think: George Floyd
Jennifer L on Think: George Floyd
Carlos Fisher on Think: George Floyd
Jose "cheMMa" Rodriguz on Think: George Floyd
Aniza Thomas on Think: George Floyd
David Seay on Think: George Floyd
Marc LJ on Think: George Floyd
andre edwards on Think: George Floyd
Terelle Jerricks on From Pop Culture to Cop Culture
Sharon Hislop on Think: George Floyd
Fetteroff on Think: George Floyd
Raul Acevedo Jr. on Think: George Floyd
Mel Grayson on Think: George Floyd
Terelle Jerricks on A Virtual World of Events 
Alice r. Knoop on Lung Health Tips for COVID-19
Melina Paris on Take me to Sardine
Joshua E Chambers on Take me to Sardine
Chad Dorchester on Take me to Sardine
Terelle Jerricks on Change Won’t Be Televised
Melina Paris on Take me to Sardine
Melina Paris on Take me to Sardine
Melina Paris on Take me to Sardine
Bob Kohler on About
Judie M Barker on About
Kim Kaufman on Staff
Kim Kaufman on Staff
Vivian Morales on From War to Lowrider
Robin Doyno on Staff
Publisher on About
Joe Stackhouse on Advertise
Marshariki Haylock on A Stabbing in San Pedro
CARRIE MENDOZA on A Stabbing in San Pedro
Martin Palmiere EMC(SW) ret. on Trouble on the Iowa
Martin A.Palmiere EMC(SW) USN(ret.) on Trouble on the Iowa
John H Winkler on Frequently Asked Questions
J. McVey on Staff
Malou Mariano on Tampering and Collusion
Terrell Williams on The New Gap Band Fills The Gap
Alton C . Thompson, Ph. D. on About
Harold Ericsson on Letters to the Editor
Hillbinkel on Trouble on the Iowa
Ian Gordon on KKJZ Leaves CSULB Campus
larry lebedin on KKJZ Leaves CSULB Campus
Joseph Bianco on Frequently Asked Questions
Deborah Steed on Zerby Family Finds Solace
Don Griffin on Rosenberg
Pete on About
Anne Marie Knudsen on Clem Pennington is the Whole Package
Terelle Jerricks on About
Lyn Jensen on Go Retro with Records
Steven R. Heldt on Fig Trees Are Like Democracies
Joanne Sims on Peacocks, Paseo, Politics
Dave Borst-Smith on Peacocks, Paseo, Politics
Charles Traupmann on The Buscaino Report:
james P. Allen on Across the Great Divide
Allyson Vought on Across the Great Divide
PBinLostAngeles on RL NEWS Roundups: June 14, 2016
davehall on Voter Guide
Chris formica Gringos Tacos on Food Truck Blues
Random Lengths News on Iowa Fever
Tinisha Rodrique on IMG_1761
polos fred perry on Less Than a Side Show
cheap soccer jersey on Less Than a Side Show
le mahjong gratuit on The Surrealness of Knives and Breast
Harry and the Gang on Sherlock Holmes at the LB Playhouse
neufert architect s data pdf on IMG_1761
sewing machine reviews on Annie at the Warner Grand